Vitamin B8 (Mayo Inositol)

April 19, 2018

Another ingredient where Akua Life upgraded the potency of the common compound vitamin

 B8 to Mayo Inositol. Mayo Inositol does all v

itamin B8 does and more and it is more bioavailable.


The following is quoted from with written authorized permission from David Tomen the author and creator of the, the true authority on nootropics.

Vitamin B8 (Inositol, cyclohexanehexol) is a sugar alcohol and isomer of glucose found in nearly all animals and plants.

Vitamin B8 is known to decrease anxiety, depression, panic attacks, mood swings, Obsessive-Compulsive Disorder and alleviate the symptoms causing bulimia.

Inositol is a group of 9 molecules called stereoisomers. In this article, we’re talking primarily about myo-inositol which accounts for up to 95% of the inositol in your body. 

Vitamin B8 is no longer considered a ‘true’ vitamin because our body makes inositol. And we can get it from most types of food.

Myo-inositol is involved in cell-signaling. In the simplest terms, myo-inositol hears from the first neuron that it’s about to fire over a neurotransmitter. And passes that information on to the receiving neuron. Not enough inositol and the neurotransmitter can’t do its job.

Inositol is one busy molecule in your body:

  • Myo-inositol affects mRNA which regulates cell volume.
  • Phosphatidylinositol signaling pathways control signals inside and outside of brain cells.
  • Inositol plays a role in DNA repair
  • Inositol affects long-term potentiation
  • Myo-inositol is a component of cell membranes
  • Myo-inositol regulates cell metabolism
  • Myo-inositol regulates cell energy consumption

How does Vitamin B8 (Inositol) work in the Brain?

Vitamin B8 (Inositol) boosts brain health and function in several ways. But two, in particular, stand out.

  • Inositol influences neuroplasticity and neurotransmittersTranscranial Direct Current Stimulation (tDCS) has been used to treat depression, Parkinson’s Disease, stroke, and pain. But the maximum effect of tDCS in the brain was not until several minutes after treatment. Which indicates the effects of tDCS is not by direct neurotransmitter action like you would expect for example if you were using a nootropic.
  • Researchers concluded the effect of tDCS was best explained by the activation of a ‘secondary messenger system’, and modulation of brain cell membrane proteins
  • Neurotransmitters, neuromodulators, and hormones have been shown to exert their action via an intracellular (inside the cell) secondary messenger system in which the activated neuroreceptor stimulates the turnover of inositol phospholipids.

    Clinical studies have found that low levels of inositol are present in patients with anorexia, brain disorders, and depression. And abnormal levels of myo-inositol in middle-aged adults can signal the initial stages of cognitive decline such as Alzheimer’s and dementia.

  • Inositol helps reduce anxiety and depressionLong-term potentiation needed for encoding long-term memories, and long-term depression, rely on neural signal transmission and synapticplasticity. And both are strongly influenced by the myo-inositol and phosphoinositide pathway. A meta-analysis and systematic review of clinical studies were evaluated comparing inositol for depression and anxiety disorders. The researchers concluded that inositol was beneficial for treating depression and anxiety.

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